Conditions Basics

What is avascular necrosis (osteonecrosis)?

Avascular necrosis is bone death that occurs when the blood supply to the bones is decreased or stopped. Without an adequate blood supply, the bone breaks down and dies and collapses. If the bone affected is near a joint, the joint may also collapse. Avascular necrosis may affect bones of the foot and ankle, although it is a condition that more often affects long bones, such as the hip.

Avascular necrosis is also called osteonecrosis, aseptic necrosis, or ischemic bone necrosis.

What causes it?

An injury, such as a forceful impact, or a complication of a fracture or dislocation can lead to avascular necrosis. Diseases such as sickle cell disease, gout, and lupus also may lead to avascular necrosis.

Long-term use of corticosteroids or drinking a large amount of alcohol over a long time increases the risk of avascular necrosis.

What are the symptoms?

Symptoms include mild to moderate pain, decreased joint movement, and a limp. Pain may be sudden and become worse with standing or walking. Rest usually relieves the pain. Avascular necrosis occurs most often in men between 40 and 50 years old.

How is avascular necrosis (osteonecrosis) treated?

Doctors usually start with treatments to limit further damage to the bone and joint and to help the bone to grow. Treatments may include medicines, exercises, and electrical stimulation as well as limiting weight-bearing on the joint. Anti-inflammatory drugs (NSAIDs) may be prescribed to reduce pain. Eventually, most people with avascular necrosis need surgery.